ea0031oc3.1 | Reproduction, growth and development | SFEBES2013
Jean-Alphonse Frederic
, Bowersox Shanna
, Chen Stanford
, Beard Gemma
, Puthenveedu Manojkumar
, Hanyaloglu Aylin
G protein-coupled receptors (GPCRs) are one of the largest families of the mammalian genome and represent the single most common therapeutic target. The glycoprotein hormones; LH and human chorionic gonadotrophin, act at a single GPCR the LH/hCGR, whose roles in reproductive function and pregnancy are well known. Endocytic trafficking of GPCRs represents a key mechanism in defining cellular responses in complex signaling pathways by controlling both the temporal and spatial pa...